Boyang Wang 汪博洋

  PhD Student

  Automation

  Tsinghua University

  Email: wang-by20@mails.tsinghua.edu.cn

I am a PhD student at Automation, Tsinghua University, advised by Prof. Shao Li.

My research interest lies in Bioinformatics, AI in TCM, AI in Biomedicine and CRISPR system design.

My specific research areas include novel drug development based on bioinformatics analysis, as well as association prediction and protein design using network models, graph deep learning models, sequence deep learning models, and set deep learning models.

Leveraging Network Target Theory for Efficient Prediction of Drug‐Disease Interactions: A Transfer Learning Approach
Qingyuan Liu*, Zizhen Chen*, Boyang Wang*, Boyu Pan*, Zhuoyu Zhang, Miaomiao Shen, Weibo Zhao, Tingyu Zhang, Shao Li, Liren Liu
* indicates equal contribution.
Advanced Science, 2025.
Paper

Comparison of Jinzhen Oral Liquid and Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution in the Treatment of Acute Bronchitis in Children: A Multicenter, Non-inferiority, Prospective, Randomized Controlled trial
Qinhua Fan*, Chongming Wu*, Yawei Du*, Boyang Wang*, Yanming Xie, Zeling Zhang, Wenquan Su, Zizhuo Wang, Changchang Xu, Xueke Li, Ying Ding, Xinjiang An, Jing Chen, Yunying Xiao, Rong Yu, Nan Li, Juan Wang, Yiqun Teng, Hongfen Lv, Nian Yang, Yuling Wen, Xiaoli Huang, Wei Pan, Yufeng Liu, Xueqin Xi, Qianye Zhao, Changshan Liu, Jian Xu, Haitao Zhang, Lie Zhuo, Qiangquan Rong, Yu Xia, Qin Shen, Shao Li, Junhong Wang, Shengxian Wu
* indicates equal contribution.
Acta Pharmaceutica Sinica B, 2024.
Paper

Elucidating the role of artificial intelligence in drug development from the perspective of drug-target interactions
Boyang Wang*, Tingyu Zhang*, Qingyuan Liu*, Chayanis Sutcharitchan, Ziyi Zhou, Dingfan Zhang, Shao Li
* indicates equal contribution.
Journal of Pharmaceutical Analysis, 2024.
Paper

Uncovering the role of traditional Chinese medicine in immune-metabolic balance of gastritis from the perspective of Cold and Hot: Jin Hong Tablets as a case study
Boyang Wang*, Lihao Xiao*, Pan Chen*, Tingyu Zhang, Peng Zhang, Liang Cao, Ziyi Zhou, Haibo Cheng, Tong Zhang, Shao Li
* indicates equal contribution.
Chinese Medicine, 2024.
Paper

Exploring the effect of Weifuchun capsule on the toll-like receptor pathway mediated HES6 and immune regulation against chronic atrophic gastritis
Boyang Wang*, Wuai Zhou*, Huan Zhang*, Weihua Wang, Bo Zhang, Shao Li
* indicates equal contribution.
Journal of Ethnopharmacology, 2023.
Paper

Uncovering the mechanisms of Yi Qi Tong Qiao Pill in the treatment of allergic rhinitis based on Network target analysis
Boyang Wang, Dingfan Zhang, Tingyu Zhang, Chayanis Sutcharitchan, Jianlin Hua, Dongfang Hua, Bo Zhang, Shao Li
Chinese Medicine, 2023.
Paper

Biological mechanism of Traditional Chinese Medicine Formula and Herbs in Treating Diseases from the perspective of Cold and Hot
Boyang Wang, Pan Chen, Peng Zhang, Shao Li
World Journal of Traditional Chinese Medicine, 2024.
Paper

Network-based cancer precision prevention with artificial intelligence and multi-omics
Peng Zhang, Boyang Wang, Shao Li
Science Bulletin, 2023.
Paper

Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine
Peng Zhang, Dingfan Zhang, Wuai Zhou, Lan Wang, Boyang Wang,Tingyu Zhang, Shao Li
Briefings in Bioinformatics, 2024.
Paper

Network Pharmacology for Traditional Chinese Medicine in the Era of Artificial Intelligence
Weibo Zhao, Boyang Wang, Shao Li
Chinese Herbal Medicine, 2024.
Paper

Cold and Hot syndromes in traditional Chinese medicine: Insights from the perspective of immunometabolic homeostasis
Pan Chen, Boyang Wang,Peng Zhang, Shao Li
World Journal of Traditional Chinese Medicine, 2024.
Paper

Recent advances in traditional Chinese medicine network pharmacology: Integration of network target with artificial intelligence and multi-modal multi-omics technologies
Ziyi Wang, Tingyu Zhang, Boyang Wang, Shao Li
Chinese Journal of Natural Medicines, 2024.
Paper

Research and development practice of traditional Chinese medicine based on network target theory and technology
Shao Li, Boyang Wang, Liang Cao, Lihao Xiao, Pan Chen, Bo Zhang, Xinzhuang Zhang, Wei Xiao
China Journal of Chinese Materia Medica, 2023.
Paper

Network Target Theory, Key Techniques and Applications in Traditional Chinese Medicine
Li Shao, Zhang Peng, Wang Xin, Zhang Bo, Boyang Wang
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology, 2022.
Paper

Uncovering the metabolic reprogramming of macrophages for Gegen Qinlian Decoction in alleviating meta-inflammation of T2DM
Zezheng Gao*, Boyang Wang*, Han Wang*, et al.
* indicates equal contribution.
Corresponding author: Yanxiang Li, Linhua Zhao, Shao Li, XiaoLin Tong
Signal Transduction and Targeted Therapy, in revision.

MUSE: Mutation Screening via Network Enhancement
Tao Hu*, Boyang Wang*, et al.
* indicates equal contribution.
Corresponding author: Anlong Xu, Shao Li, Chunyi Hu
Advanced Science, in revision.

Systematic Development of Multi-Component Drug from Traditional Medicine: Targeting EGFR-PCNA Axis through Synergistic Danggui Sini Decoction-derived Compounds in Gastric Cancer
Boyu Pan*, Boyang Wang*, et al.
* indicates equal contribution.
Corresponding author: Shao Li, Liren Liu
Nature Communications, under review.

AI-Driven Protein Optimization for Enhanced Protein Functionality
Boyang Wang*, Tao Hu*, et al.
* indicates equal contribution.
Corresponding author: Shao Li, Chunyi Hu
Nature Biotechnology, under review.

An AI-Accelerated Discovery of Phage Protein Inhibitors
Boyang Wang*, Tao Hu*, et al.
* indicates equal contribution.
Corresponding author: Chunyi Hu
Nature, under review.

Screening the Homologous Food and Medicine Laminaria japonica as a Dietary Intervention for Fructose-accelerated CAC tumorigenesis
Tao Zhang*, Boyang Wang*, et al.
* indicates equal contribution.
Corresponding author: Bo Zhang, Shao Li, Yang Sun
Nature Foods, under review.

A Phenotype-Molecular Transfer Learning Model: Clinical Analysis and Mechanistic Insights of Yinqiao Qingre Pill in Wind-Heat Cold Intervention
Boyang Wang*, Tingyu Zhang*, et al.
* indicates equal contribution.
Corresponding author: Wei Xiao, Shao Li, Yongyan Wang
Acta Pharmaceutica Sinica B, under review.

Revealing the Mechanisms of Compound Kushen Injection in the Treatment of Radiation-Induced Lung Injury and Lung Cancer: From Regulating Oxidative Stress to Modulating Macrophages
Boyang Wang, Defei Kong, et al.
Corresponding author: Kun Li, Shao Li
Acta Pharmaceutica Sinica B, under review.

Leveraging Transfer Learning and Set-structure Deep Learning for Directional and Genome-wide Target Prediction in Complex Compounds System
Boyang Wang, Boyu Pan, Tingyu Zhang, et al.
Corresponding author: Shao Li
Science Bulletin, under review.

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network
Weibo Zhao*, Boyang Wang*, et al.
* indicates equal contribution.
Corresponding author: Shao Li, Qi Wang
Chinese Medicines, under review.

A computational based new treatment strategy with randomized, double-blind, three-armed, parallel-controlled, multicenter clinical trials on Mycoplasma pneumoniae pneumonia in children
Chengliang Zhong*, Shengxuan Guo*, Qingyuan Liu*, Deyang Sun*, Boyang Wang*, et al.
* indicates equal contribution.
Corresponding author: Shao Li, Rong Ma
Chinese Medicines, in revision.

Regulation of Cell Cycle by Pien Tze Huang in preventing Hepatocellular carcinoma progression
Tingyu Zhang*, Weibo Zhao*, Pan Chen*, et al.
* indicates equal contribution.
Corresponding author: Boyang Wang
Phytomedicine, in revision.

A network-based biomarkers discovery of Cold/Hot ZHENG chronic gastritis and Cold/Hot herbs of formulae
Boyang Wang, Pan Chen, Peng Zhang, Shao Li
arxiv, 2023, arXiv:2302.05450.
Paper

Clinical multi-omics reveals the role of Tuomin Zhiti Decoction Intervention in Allergic Rhinitis from the perspective of biological network
Weibo Zhao*, Boyang Wang*, Lingyao Kong, Qi Wang, Shao Li
* indicates equal contribution.
medrxiv, 2024, medRxiv 2024.03.10.24303911.
Paper

Network pharmacology on the mechanism of Yi Qi Tong Qiao Pill inhibiting allergic rhinitis
Boyang Wang, Dingfan Zhang, Tingyu Zhang, Chayanis Sutcharitchan, Jianlin Hua, Dongfang Hua, Bo Zhang, Shao Li
arxiv, 2023, arXiv:2305.04931.
Paper

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction
Xiaoning Gao, Bo Zhang, Peiyuan Liu, Mingyue Yuwen, Zixiang Liu, Ruyang Tan, Boyang Wang, et al.
arxiv, 2024, bioRxiv 2024.01.06.574490.
Paper

The regulatory role of JZOL on TRP channels in the treatment of Acute Bronchitis based on the combination of clinical trials, computational analysis and in vivo experiments
Qinhua Fan*, Chongming Wu*, Yawei Du*, Boyang Wang*, et al.
medrxiv, 2024, medRxiv 2024.05.07.24306993.
* indicates equal contribution.
Paper

Unveil the mechanism of Jinzhen Oral Liquid combined with Azithromycin in the treatment of Mycoplasma pneumoniae pneumonia based on Network pharmacology and clinical trials
Chengliang Zhong*, Shengxuan Guo*, Qingyuan Liu*, Deyang Sun*, Boyang Wang*, et al.
medrxiv, 2024, medRxiv 2024.06.27.24309347.
* indicates equal contribution.
Paper